Epitope analysis for influenza vaccine design
نویسندگان
چکیده
منابع مشابه
Epitope analysis for influenza vaccine design.
Until now, design of the annual influenza vaccine has relied on phylogenetic or whole-sequence comparisons of the viral coat proteins hemagglutinin and neuraminidase, with vaccine effectiveness assumed to correlate monotonically to the vaccine-influenza sequence difference. We use a theory from statistical mechanics to quantify the non-monotonic immune response that results from antigenic drift...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2005
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2004.08.028